Our overall goal is to greatly improve the knowledge on the dog genome as a model for human health. The project will generate the most comprehensive functional information source of the dog genome to facilitate the highest resolution gene mappings for disease, morphology and behaviour. This will be exemplified by identifying risk variants for common brain diseases.
Our specific aims involve the following:
Generate the most complete genome annotation atlas for the dog including the wolf
Describe commonalities and differences between human and dog genes, including gene regulatory regions that are essential for using the dog as model for human diseases
Provide the dog genome annotation atlas to the scientific community as valuable resource including an elegant database system, similar to the FANTOM database
Utilize new genomic resources to identify new risk genes and variants in canine brain disorders such as epilepsy, anxiety and neurodegeneration as models to the corresponding human conditions
Towards these aims, the project will
Generate a fresh tissue biobank from dogs and wolves (~120 tissues)
Utilize transcriptomics approaches such as STRT and CAGE to generate the massive data for annotation
Create necessary bio-IT resources, databases and genome browsers to analyse and provide access to the data.