Our first major paper, now published in Nature Communications, unveils over 100,000 canine promoter regions. DoGA provides a comprehensive gene expression atlas, accelerating discovery in both dog and human health. Explore our interactive resources to delve into canine biology, from development to disease.

The DoGA consortium expression atlas of promoters and genes in 100 canine tissues
Hörtenhuber, M., Hytönen, M. K., Mukarram, A. K., Arumilli, M., Araujo, C. L., Quintero, I., Syrjä, P., Airas, N., Kaukonen, M., Kyöstilä, K., Niskanen, J., Jokinen, T. S., Mottaghitalab, F., Takan, I., Salokorpi, N., Raman, A., Stevens, I., Iivanainen, A., Yoshihara, M., Gusev, O., … Lohi, H. (2024). The DoGA consortium expression atlas of promoters and genes in 100 canine tissues. Nature communications, 15(1), 9082.

Our second paper using the same tissue biobank but with CAGE-based transcriptomics for new promoters and enhancers has been submitted and can be found in bioarxive:

The DoGA Consortium Atlas of Canine Enhancers and Promoters Across Tissues and Development, Isil Takan, Matthias Hortenhuber, Noora Salokorpi, Rijja Bokhari, Cesar Araujo, Rasha Aljelaify, Ileana Quintero, Sini Ezer, Faezeh Mottaghitalab, Amitha Raman, Fiona Ross, DoGA Consortium, Tarja Jokinen, Pernilla Syrja, Danika Bannasch, Antti Iivanainen, Marjo K Hytonen, Juha Kere*, Hannes Lohi*, Carsten O. Daub*. bioRxiv 2026.03.24.713649; doi: https://doi.org/10.64898/2026.03.24.713649

This study describes the detailed protocol for the STRT libraries and sequencing to produce 5’ transcriptomics data:

Generation of RNA sequencing libraries for transcriptome analysis of globin-rich tissues of the domestic dog. Ezer S, Yoshihara M, Katayama S; DoGA consortium; Daub C, Lohi H, Krjutskov K, Kere J. STAR Protoc. 2021 Dec 12;2(4):100995.

These are examples of papers utilizing parts of the resources and data developed by the DoGA Consortium:

Dog colour patterns explained by modular promoters of ancient canid origin. Bannasch DL, Kaelin CB, Letko A, Loechel R, Hug P, Jagannathan V, Henkel J, Roosje P, Hytönen MK, Lohi H, Arumilli M; DoGA consortium; Minor KM, Mickelson JR, Drögemüller C, Barsh GS, Leeb T. Nat Ecol Evol. 2021 Oct;5(10):1415-1423.

A putative silencer variant in a spontaneous canine model of retinitis pigmentosa. Kaukonen M, Quintero IB, Mukarram AK, Hytönen MK, Holopainen S, Wickström K, Kyöstilä K, Arumilli M, Jalomäki S, Daub CO, Kere J, Lohi H; DoGA Consortium. PLoS Genet. 2020 Mar 9;16(3):e1008659.